Stub1 chip

Author: vjdd

August undefined, 2024

WebNov 16, 2024 · STUB1 disassociates AR/AR-V7 from HSP70, leading to AR/AR-V7 ubiquitination and degradation. ... The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat. Cell ... WebApr 8, 2024 · More interestingly, the E3 ubiquitin ligase STIP1 homology and U-box containing protein 1 (STUB1, also known as CHIP and encoded by STUB1) emerged as …

STUB1 Gene - GeneCards CHIP Protein CHIP Antibody

WebRecently, the carboxyl terminus of Hsp70-interacting protein (CHIP), also known as STIP1 homology and U-box containing protein 1 (STUB1), has been identified as a critical regulator of necroptosis . CHIP is a 34.5-kDa cytoplasmic protein comprising the N-terminal tetratricopeptide (TPR) domain, C-terminal U-box domain, and a central coiled-coil ... CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the stress recovery process. Hence CHIP appears to maintain protein homeostasis by controlling chaperone levels during stress and recovery. Mutations in STUB1 cause spinocerebellarataxiatype 16. Interactions. STUB1 … See more STUB1 (STIP1 homology and U-Box containing protein 1) is a human gene that codes for the protein CHIP (C terminus of HSC70-Interacting Protein). See more The CHIP protein encoded by this gene binds to and inhibits the ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the … See more • Patterson C (Jan 2002). "A new gun in town: the U box is a ubiquitin ligase domain". Science's STKE. 2002 (116): pe4. doi See more STUB1 has been shown to interact with: • C-Raf, • DNAJB1, • HSPA1A, • HSPA4, See more • STUB1 human gene location in the UCSC Genome Browser. • STUB1 human gene details in the UCSC Genome Browser. See more logement shawinigan sud

Cancers Free Full-Text Prognostic Significance of CHIP and …

WebSTUB1/CHIP Antibody (A301-572A) in WB Detection of human and mouse STUB1/CHIP by western blot (h&m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), 293T … WebSTUB1 encodes for the protein C-terminus of Hsc70 Interacting Protein (CHIP), an E3 ubiquitin ligase. CHIP is known to regulate proteostasis by recruiting chaperones via a N-terminal… Show more WebSep 24, 2024 · The ubiquitin ligase CHIP (C-terminus of Hsc70-interacting protein) is encoded by STUB1 and promotes ubiquitination of misfolded and damaged proteins. CHIP deficiency has been linked to several diseases, and mutations in the human STUB1 gene are associated with recessive and dominant forms of spinocerebellar ataxias (SCAR16/SCA48). industrial bathroom door locks

Human Gene STUB1 (ENST00000565677.5) from GENCODE V43

Recombinant Human CHIP/STUB1 Protein, CF E3-220-050: R&D …

WebDetects human carboxyl terminus of hsc70-interacting protein (CHIP).Detects a band of approximately 35 kDa representing CHIP from COS-1 cells overexpressing the human … WebJul 27, 2024 · The STUB1 gene (STIP1 Homology And U-Box Containing Protein 1) encodes the CHIP protein containing tetratricopeptide repeats and a U-box that functions as a ubiquitin ligase/cochaperone, involved ... industrial bathroom door hingesWebDec 21, 2024 · PubMed Abstract: Recent evidence suggests that deletion of STUB1─a pivotal negative regulator of interferon-γ sensing─may potentially clear malignant cells. … industrial bathroom ideas racks

"WebMar 26, 2024 · CHIP/STUB1 Antibody (C-10) is a mouse monoclonal IgG 1 κ, cited in 16 publications, provided at 200 µg/ml raised against amino acids 73-303 mapping at the C-terminus of CHIP of human origin Anti-CHIP/STUB1 Antibody (C-10) is recommended for detection of CHIP of mouse, rat and human origin by WB, IP, IF and ELISA " - Stub1 chip

Stub1 chip

WebBrowse the : « Home » page. Food Basics, always more for less! WebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity …

Did you know?

WebSynthetic peptide within Human STUB1/CHIP aa 1-100 (N terminal). The exact sequence is proprietary. Positive control HeLa, MCF-7, 293T and ECV-304 cell lysates; Human skeletal muscle tissue. General notes This … WebSep 9, 2024 · Carboxy-terminus of Hsc70-interacting protein (CHIP), also termed STUB1, is a 35 kDa protein with the dual function of co-chaperone and E3 ubiquitin ligase activity 3,4.

WebSTIP1 Homology and U-box Containing Protein 1 (STUB1), also known as Carboxyl Terminus of Hsp70-interacting Protein (CHIP), is a cytoplasmic protein that functions as a U-box Ubiquitin ligase (E3) (1). It is highly expressed in striated muscle and brain and has been observed at lower levels in other organs including the pancreas, lung, liver ... WebAug 18, 2024 · Stub1 deletion enhances antigen processing and presentation by sensitizing tumour cells to IFNγ. (a – c) Flow cytometry analysis of cell surface MHC-I on parental, control or independent Stub1...

Webnote = "Funding Information: We thank Dr. Ana Maria Cuervo for providing the shRNA against Lamp2a and Atg7 lentiviral vectors, and the NIH-3T3 cells, Dr. Thilo Hagen for the wild-type and proline mutant HIF1A constructs, Dr. Cam Patterson for the wild-type and mutant STUB1 constructs, and Dr. Roland H. Wenger for the Hif1a+/+ and hif1a−/− MEFs. WebMay 25, 2015 · STUB1/CHIP is a E3 ligase protein that ubiquitylates and tags other proteins for degradation. It is involved in major developmental processes for the downstream expression and/or stabilization of ...

WebApr 4, 2024 · Stub1 maintains proteostasis of master transcription factors in embryonic stem cells. CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation. CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.

WebDescription: Homo sapiens STIP1 homology and U-box containing protein 1 (STUB1), transcript variant 2, mRNA. (from RefSeq NM_001293197) RefSeq Summary (NM_001293197): This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and … industrial basement design ideasWebSTUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy. The transcription factor HIF1 is mostly regulated by the oxygen-dependent proteasomal … industrial bathroom lighting two bulbsWebAug 12, 2024 · updated on. August 12, 2024. On Highway 17 about an hour north of Sault Ste. Marie, Ontario at Pancake Bay and across from Agawa Crafts & The Canadian Carver, … logement nancy locationWebFull gene name according to HGNC. STIP1 homology and U-box containing protein 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. STUB1 (CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). Read more. industrial bathroom lavenderWebSTUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down’s syndrome patients. industrial bathroom imagesWebSTUB1/CHIP was also immunoprecipitated by rabbit anti-STUB1/CHIP antibody (Product # A301-573A), which recognizes a downstream epitope. For blotting immunoprecipitated … industrial bathroom lighting galvenizedWebDescription Rabbit polyclonal to STUB1/CHIP Host species Rabbit Specificity Detects human carboxyl terminus of hsc70-interacting protein (CHIP).Detects a band of approximately 35 kDa representing CHIP from COS-1 cells overexpressing the human gene including a non-specific band at 80kDa . logement lyon location pas cher