Plectin protein
Webb30 aug. 2024 · Moreover, plectin is a scaffolding protein known to bind to the receptor for activated C kinase 1 (RACK1), thus modulating protein kinase C (PKC) signaling … WebbPlectin is a cytoskeletal linker protein which has a long central rod and N- and C-terminal globular domains. Mutations in the gene encoding plectin (PLEC) cause two distinct …
Plectin protein
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WebbThe Pathology section contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analysis based on mRNA expression levels of human …
Webb9 feb. 2024 · Here, we show that plectin, a major intermediate filament-based cytolinker protein, orchestrates cortical cytoskeletal networks in epithelial sheets to support … Webb27 feb. 2024 · Plectin has been shown to bind directly to several IF proteins, including epithelial keratins (both types I and II), neurofilaments, vimentin, desmin, glial fibrillary …
WebbThe cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various cellular activities contributing to ... Webb14 okt. 2008 · Protein names Recommended name Plectin Short names PCN; PLTN Alternative names Hemidesmosomal protein 1 ( HD1) Plectin-1 Gene names Name …
Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect … Visa mer Plectin can exist in cells as several alternatively-spliced isoforms, all around 500 kDa and >4000 amino acids. The structure of plectin is thought to be a dimer consisting of a central coiled coil of alpha helices connecting … Visa mer Studies employing a plectin knockout mouse have shed light on the functions of plectin. Pups died 2–3 days after birth, and these mice exhibited marked skin abnormalities, including degeneration of keratinocytes. Skeletal and cardiac muscle tissues were also … Visa mer • Pfendner E, Rouan F, Uitto J (Apr 2005). "Progress in epidermolysis bullosa: the phenotypic spectrum of plectin mutations". Experimental … Visa mer Mutations in PLEC have been associated with epidermolysis bullosa simplex with muscular dystrophy. A missense variant of PLEC has been … Visa mer • List of target antigens in pemphigus Visa mer • Mass spectrometry characterization of one isoform of PLEC at COPaKB. • GeneReviews/NCBI/NIH/UW entry on Epidermolysis Bullosa with Pyloric Atresia • plectin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Visa mer
WebbIf one of the proteins encoded by these genes is malfunctional, this has fundamental effects on the structure and stability of the hairs, since the three proteins are involved in the same metabolic pathway and the subsequent cross-linking of hair proteins is no longer ensured. 19 Clinically, affected children present with shaggy and tousled silvery-blonde … left and right of boomWebb11 juli 2016 · RNA-binding proteins (RBPs) have essential roles in determining the fate of RNA from synthesis to decay and have been studied on a protein-by-protein basis, or computationally based on a number of ... left and right on a shipWebbWe generated EBS-Ogna knock-in mice mimicking the human phenotype and show that blistering reflects insufficient protein levels of the hemidesmosome-associated plectin isoform 1a. We found that plectin 1a, in contrast to plectin 1c, the major isoform expressed in epidermal keratinocytes, is proteolytically degraded, supporting the notion that … left and right one hourWebbPlectin Pediatric Neurology Part III. Bruno Eymard, ... ... Plectin is a highly preserved structural protein of the... Intermediate Filament Linker Proteins: Plectin and BPAG1. … left and right party gameWebbPlectin has recently been identified as a widespread and abundant cytoplasmic protein of mammalian cells. In this article the available data on plectin are reviewed, focusing on … left and right partyWebb8 jan. 2024 · The PLEC gene (PLEC is the acronym for plectin) is a protein-coding gene located on 8q24.3. Until 2010, this gene locus was named Plectin 1 (symbol PLEC1 in humans), and the gene product was referred to as "hemidesmosomal protein 1" or "Plectin 1, intermediate filament binding 500kDa". These designations have been replaced by … left and right on shipWebb21 apr. 2024 · As such, therapeutic targeting of plectin, its protein interactors, and in particular, cancer-specific plectin (CSP), presents an attractive opportunity to impede carcinogenesis directly”. The article reports on plectin’s differential gene and protein expression in cancer, explores its mutational profile, and discusses the current … left and right ovary pain early pregnancy