Mitf protein atlas
Web28 sep. 2024 · The authors also conducted an in silico analysis using TCGA Pan-Cancer-Atlas data to confirm that patients with MITF-E318K melanoma carriers harboured a common pattern of 9p21.3 deletion. The overall results provided greater insights into the clinical strategies that could be used to manage and treat MITF-associated tumour types. WebOverview of the celline expression of MITF. Protein detected at medium/high level in 4 cell lines. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. ... The Human Protein Atlas project is funded
Mitf protein atlas
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Web6 jul. 2016 · Objective: This study investigated the role and mechanism of action of G protein-coupled estrogen receptor (GPER) in melanogenesis. Methods: GPER expression was detected in the A375 human melanoma cell line and B16 mouse melanoma cell line. Cell proliferation, melanin content, tyrosinase (TYR) activity, cyclic adenosine … WebWe show that BRAF induces MITF transcription through the MEK/ERK cascade and the transcription factor BRN2. Thus, we propose that oncogenic BRAF down-regulates the MITF protein by targeting it for degradation in an ERK-dependent manner, but then counters this by stimulating MITF transcription in a BRN2-dependent manner.
Web3 aug. 2015 · Because of the demand on lysosomal function by mitophagy, we investigated a role for the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in this process. We show that during mitophagy TFEB translocates to the nucleus and displays transcriptional activity in a PINK1- and Parkin-dependent manner. WebThe protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte … General description of the gene and the encoded protein (s) using information … MITF antibodies. PROTEIN STRUCTUREi. The Structure section provides predicted … MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro … MITF. General description of the gene and the encoded protein (s) using … blood protein i Summary of data presented in the Blood proteins section and a … mitf. sections. tissue brain single cell type tissue cell type pathology disease … HUMAN PROTEIN ATLAS INFORMATIONi. Summary of RNA … HUMAN PROTEIN ATLAS INFORMATIONi. Summary of RNA …
http://genome.cse.ucsc.edu/cgi-bin/hgGene?hgsid=1604921059_rVn1WbQrVVz6m7V7RtaRB8ojEueA&hgg_section_method_close=1 WebThe activity and degradation of MITF-M are regulated by extracellular signals via protein phosphorylation, such as c-Kit signaling. Together, multiple signals appear to converge on the M promoter as well as on MITF proteins, leading to the proper regulation of MITF-M in melanocytes and other MITF isoforms in many cell types.
Web抗-MITF 兔抗 Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution; ... Human Protein Atlas-Nummer: HPA003259. Recommended Products. Slide 1 of 10. 1 of 10. Sigma-Aldrich. SAB4501879. Anti-MITF antibody produced in rabbit.
Web3 sep. 2024 · MITF is crucial for melanocyte development and differentiation, and has been termed a lineage-specific oncogene in melanoma. The three related proteins MITF, TFEB and TFE3 have been shown to be involved in the biogenesis and function of lysosomes and autophagosomes, regulating cellular clearance pathways. metaphysical stores des moines iowaWebProduct Description Polyclonal Antibody against Human MITF Alternative Gene Names bHLHe32, MI, WS2, WS2A Open Datasheet Price $505.00 Product Number HPA003259 Unit Size Concentration 0.1 mg/ml Availability >10 in Stock Ships Ready to Ship Share by E-mail Add to Cart Show all images [5 pictures] metaphysical stores in delawareWeb15 jul. 2002 · The MITF cDNA was excised with EcoRI and subcloned into vector pCMV5a (Sigma Chemical Co., St Louis, MO). The orientation and sequence of the MITF cDNA was verified by automated DNA sequencing. Expression of functional MITF protein was verified by co‐transfection of pCMV5a‐MITF with a TYRP1 promoter plasmid in HeLa cells. Gel … how to achieve full employment economicsWebThe Human Protein Atlas version in which the antibody was first released is given. The antigen type, length (amino acid residues), and sequence is reported (if available) under … how to achieve first aid qualificationWebMiTF is Associated with Chemoresistance to Cisplatin in A549 Lung ... containing PMSF (Sigma-Aldrich) and protease inhibitors (Thermo Fisher Scientific, Waltham, MA, USA). The protein concentrations of cell lysates were determined by the BCA Assay Kit (Bio-Rad ... We analyzed the lung patients’ data from The Cancer Genome Atlas ... metaphysical stores in bakersfield caWebprotein_coding_gene Location ... Waardenburg's syndrome; and familial melanoma. Orthologous to human MITF (melanocyte inducing transcription factor). Genome Resources. Alliance ; Gene:30080 ; VEGA:OTTDARG00000019915 ; Ensembl(GRCz11):ENSDARG00000003732 ; Note None Comparative ... Expression … how to achieve functional equivalenceWebGene information about ENSG00000187098 / MITF - microphthalmia-associated transcription factor We use cookies to enhance the usability of our website. If you … how to achieve flow state