Cisplatin lung toxicity

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August undefined, 2024

WebNov 29, 2024 · Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment Yanyun Gao, Patrick Dorn, Shengchen Liu, Haibin Deng, Sean R. R. Hall, Ren-Wang Peng, Ralph A. Schmid & Thomas M. Marti Cancer Cell International 19, Article number: 317 ( 2024 ) … WebClinical Comparative Investigation of Efficacy and Toxicity of Cisplatin plus Clinical comparative investigation of efficacy and toxicity of cisplatin plus gemcitabine or plus Abraxane as first-line chemotherapy for stage III/IV non-small-cell lung cancer Dan Ai,1,2 Yan Guan,2 Xiu-Ju Liu,2 Chu-Feng Zhang,1,2 Peng Wang,1,2 Hong-Lu Liang,1,2 Qi …

Cisplatin nephrotoxicity - UpToDate

WebFeb 22, 2024 · Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung cancer (NSCLC), which is extremely difficult to treat and its survival rate is low. After decades of clinical trials, the most effective treatments are still those that implement the … WebJun 1, 2013 · It has been shown that cisplatin administration induced a large amount of NO, which may lead to a greater formation of ROS and RNS causing cellular damage (Chirino et al., 2004, Demkow et al., 2011). A toxic role for nitric oxide itself or by generation of nitrosative stress has also been described. c\u0027s by the sea

Clinical Significance of Long Non-Coding RNA

WebThus, the SNP rs10505477 in CASC8 may serve as an underlying risk marker for detecting and diagnosing lung cancer, and could be used to determine the response and toxicity … WebDec 7, 2024 · In the present study, the carboplatin-containing regimen was associated with a higher incidence of thyroid and pulmonary toxicity. Therefore, for patients with co … WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose limiting. east anglian traction engine society

Targeted therapy for cisplatin‐resistant lung cancer via …

Gemcitabine-induced pulmonary toxicity - PubMed

WebPulmonary toxicity of cytotoxic agents Platinum compounds The administration of cisplatin and carboplatin, the 2 most commonly used platinum derivative agents, can lead to … WebMyelosuppression is the most common toxicity of gemcitabine therapy. Pulmonary toxicities due to gemcitabine have, however, been reported. Dyspnea occurs in approximately 25% of patients treated with gemcitabine, whereas serious pulmonary toxicities are much less common, approximately 0.3%. c\u0027s catering service 株WebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II study, concurrent chemoradiotherapy with TPF achieved a clinical CR rate of 52.4%, much higher than the previously reported CR rate of 20%. 9 However, the high ... c\u0027s candy company

"WebDec 1, 2024 · Dose adjustments for both docetaxel and cisplatin were performed according to pre-defined criteria for each type of toxicity (mainly grade 4 neutropenia and grade 3–4 neuropathy). Two dose reductions were allowed for DC75 (first to 60 mg/m 2, second to 50 mg/m 2), but only 1 reduction was allowed for DC60 and DCM therapy (to 50 mg/m 2). … " - Cisplatin lung toxicity

Cisplatin lung toxicity

WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Targeted therapy for cisplatin-resistant lung cancer via aptamer-guided nano-zinc carriers containing USP14 siRNA. Xinmin Zhao, ... Some chronic toxicity was observed in the 10 mg ... WebMar 22, 2024 · Pulmonary toxicities occur in 10% of treated patients. In approximately 1%, the nonspecific pneumonitis induced by Bleomycin progresses to pulmonary fibrosis and death. Although this is age and …

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WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Targeted … WebThis suggests that cisplatin-induced lung damage can damage the cilia, manifesting as increased ciliary proteins in the BALF. By increasing oxidative stress in the lung, …

WebChemotherapy-related cardiac toxicity is a rare but serious adverse event in patients with cancer. Thus far, no case of serious cardiac toxicity of pemetrexed has been reported. We describe the case of a patient with advanced lung cancer and cardiomyopathy due to … WebTolerability and toxicity of adjuvant cisplatin and gemcitabine for treating non-small cell lung cancer Cisplatin and gemcitabine are feasible for use in the adjuvant setting with a favorable toxicity profile and superior tolerability compared with published data on cisplatin and vinorelbine.

WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, mesothelioma, ovarian cancer, and bladder cancer. It is also used prior to bone marrow and stem cell transplantation. WebClinical Comparative Investigation of Efficacy and Toxicity of Cisplatin plus Clinical comparative investigation of efficacy and toxicity of cisplatin plus gemcitabine or plus …

WebJan 23, 2024 · The major toxicities occur in the lung and skin, where the drug is concentrated. Up to 20% of patients treated with bleomycin develop clinical pulmonary …

WebJun 1, 2016 · The carboplatin-docetaxel arm had a more favourable toxicity profile and a significant number of patients withdrew from the cisplatin-docetaxel doublet due to grade 3–4 emesis ( Greco et al., 2000 ). Other studies have observed the efficacy and tolerability of platinum-gemcitabine regimens in CUP. c\\u0027s barber shop fairfield caWebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and monitor renal function and electrolytes. Consider dose reduction or alternative treatments in patients with renal impairment. PERIPHERAL NEUROPATHY: east anglian van hireWebovarian, testicular, head, neck and small cell lung cancer for the last four decades1. Acquired resistance following initial use in ovarian and small cell lung carcinoma has been documented, whereas tumors like colorectal ... toxicity of Cisplatin in a median follow up time of 58 months identified cardiovascular risk factors in one third c\u0027s cafe in middlefieldWebSep 4, 2013 · Short hydration is safe and reduces the frequency of severe renal toxicities in regimens containing cisplatin (≥75 mg/m 2) for the treatment of patients with lung cancer. Cisplatin labels with regard to hydration should accept short- and lower-volume hydration as an option based on the result of the present study. Funding c\u0027s chocolateWebOct 7, 2024 · Cisplatin is one of the most widely prescribed chemotherapeutic drugs, used to treat a wide range of pediatric and adult malignances such as ovarian, testicular, bladder, head, neck, breast and lung [2,3]. It is prescribed … east anglian trailer centreWebNov 26, 2024 · Cisplatin-Induced Toxicity . Cisplatin, cis- diamine-dichloro-platinum (CDDP) is one of the most used chemotherapy drugs because it is effective against different types of tumors. ... Mediators such as 4-HNE and H 2 O 2 are among the most relevant secondary messengers induced by ozone during lung toxicity following airway … c\\u0027s barber shop dayton txWebAlthough the final mechanism of inducing tumour cell apoptosis is similar for both compounds, cisplatin has been shown to be more effective in treating specific tumour types. Whilst more favourable toxicity profiles are often associated with carboplatin, this can frequently translate to inferior response in certain malignancies. east anglian tiger owners club