Carboplatin ototoxicity
WebPrevention of Drug-Induced Ototoxicity. Ototoxic antibiotics should be avoided during pregnancy, because they can damage the fetal labyrinth. Older adults and people … WebCarboplatin (cis-Diammine-1,1-cyclobutane dicarboxylate platinum II; CBDCA) is a second generation platinum analog with less nephrotoxicity and cochlear ototoxicity than cisplatin, the first generation platinum chemotherapeutic agent.
Carboplatin ototoxicity
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WebAug 31, 2016 · Ototoxicity poses a major problem to the cancer patient, as the quality of life after receiving cisplatin chemotherapy may be negatively affected due to hearing loss, resulting in social, emotional, and vocational difficulties, as effective communication is … WebCarboplatin, like cisplatin, produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. This effect is apparently cell-cycle nonspecific. The …
WebTheir beneficial effect is limited by the onset of drug resistance and severe toxicities, involving mainly ototoxicity, neurotoxicity and nephrotoxicity. Recent studies highlight the supplementation of herbal products, vitamins and minerals with antioxidant properties to prevent and protect from side effects. WebSep 21, 2016 · Ototoxicity affects the inner ear, which is essential in both hearing and balance. High-dose carboplatin can also induce auditory dysfunction with a clinical picture that is largely the same as that after cisplatin therapy. 9, 10 Auditory function must be monitored carefully because the toxicity can become disabling.
WebWhile carboplatin is substantially less ototoxic than cisplatin, both can lead to serious hearing loss requiring the use of assistive listening technology, preferential classroom seating, additional educational resources, and … WebCarboplatin is more myelotoxic than cisplatin. Mechanism of action Like cisplatin, carboplatin works as an ‘atypical’ alkylator, binding and cross-linking DNA, which leads to DNA strand breakage during replication. Pharmacokinetics/metabolism Intravenous carboplatin is rapidly cleared by the kidneys, with a 2.5 h half-life.
WebThe antineoplastic agent's cisplatin and carboplatin are widely used as they are highly effective. Unfortunately, ototoxicity is a frequently encountered side effect of platinum …
WebApr 4, 2024 · Common carboplatin side effects may include: low blood cell counts; loss of appetite; nausea, vomiting, diarrhea; numbness, burning pain, or tingly feeling; … nursing workshops canadaWebFeb 27, 2012 · Carboplatin is the principal agent in all retinoblastoma chemotherapy protocols reported to date. Platinum-induced ototoxicity manifests as bilateral high … nursing workshops 2018WebOtotoxic effects of quinine are due to vasoconstriction in the small vessels of the cochlea and stria vascularis. ... Nitrogen mustard, cisplatin and carboplatin can cause cochlear damage. They affect the outer hair cells of the cochlea. Toxicity that relates to cisplatin is mostly cochlear, and causes high-frequency hearing loss due to damage ... nursing workshops near meWebOtotoxicity refers to drug-induced damage affecting the inner ear structures and related neural tissues, causing cochlear dysfunction (such as hearing loss or tinnitus) and/or vestibular dysfunction (such as vertigo, dizziness, or imbalance) or both ( … nursing worksheets downloadWebNational Center for Biotechnology Information nursing worksheets for kidsWebMar 31, 2024 · Dear Colleagues, Metal-based complexes contribute a vital part in the available arsenal of cytotoxic agents today. Platinum (II) complexes, specifically targeting genomic DNA (e.g., cisplatin and carboplatin), are widely used in the clinic for the treatment of various cancers. Nearly 50% of cancer patients, who undergo chemotherapy, receive a ... nursing workshops 2022WebJul 1, 2012 · Platinum drugs are effective chemotherapeutic agents commonly used in the treatment of a variety of adult and pediatric cancers. 1 Sixty percent of children treated with cisplatin develop permanent bilateral hearing loss. 2, 3 Although cisplatin is more ototoxic than other platinum-based drugs, carboplatin is also ototoxic, especially when … no charges for gaetz